Police from 51 Division responding to a report of multiple stabbings near Sherbourne and Dundas Street East.
The call came into paramedics at 7:26, Saturday morning.
A male victim was sent hospital in serious condition, while a female transported in stable condition.
Police now looking for a suspect reported to be a black man with a facial scar wearing a grey tracksuit He was seen driving dirty black 1 tonne dually truck with silver equipment box in back.
Anyone with information on the incident is encouraged to call police or CrimeStoppers.