The Honda Indy may not get underway until Friday but road closures will be in effect from Wednesday to allow for set up.
At noon, southbound Strachan Avenue will be closed from Fleet Street to Lake Shore Boulevard West.
Come 8 p.m., Lake Shore Boulevard West from Strachan Avenue to British Columbia Drive will also be closed off.
The road closures will remain in place until Sunday at 11.p.m.
Drivers are being advised to plan ahead and map out an alternative route or to take transit.